Nutrition & synapses Synapses consist of neuronal membranes which are composed of a type of lipid known as a phospholipid. The most abundant phospholipid in the human brain (phosphatidylcholine) is formed via a metabolic process called the Kennedy pathway. People living with early Alzheimer’s disease have been shown to have relatively low levels of a range of nutrients in their bodies despite eating a normal diet. These nutrients are required in the process of making new connections in the brain called synapses. Omega 3 fatty acids, uridine monophosphate and choline, together with several key vitamins, all work together to help this process. The loss of synapses is one of the key features of early Alzheimer’s disease.